Since the beginning of the epidemic, 92.2 million [70.1–123 million]  people have been infected with the HIV virus and about 44.2 million [33.8–61.1 million] people have died from HIV-related causes.

Globally, 41.0 million [35.3–47.5 million] people were living with HIV at the end of 2025. An estimated 0.7% [0.6-0.8%] of adults aged 15–49 years worldwide are living with HIV, although the burden of the epidemic continues to vary considerably between countries and regions.

The WHO African Region remains most severely affected, with nearly 1 in every 35 adults (2.9%) living with HIV and accounting for more than two-thirds of the people living with HIV worldwide.